2-benzyloxy-5-methoxybenzyl chloride

Base Information

• Chemical Name: 2-benzyloxy-5-methoxybenzyl chloride
• CAS No.: 214072-74-9
• Molecular Formula: C₁₅H₁₅ClO₂
• Molecular Weight: 262.736
• Mol file: 214072-74-9.mol

Synonyms:2-benzyloxy-5-methoxybenzyl chloride

Chemical Property of 2-benzyloxy-5-methoxybenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-5-methoxybenzyl chloride

There total 2 articles about 2-benzyloxy-5-methoxybenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2-(benzyloxy)-5-methoxyphenyl)methanol (214072-73-8) → 2-benzyloxy-5-methoxybenzyl chloride (214072-74-9)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; benzene; at 20 ℃; for 2h;

DOI:10.1021/jm0581718

Reference yield:

2-benzyloxy-5-methoxybenzaldehyde (56979-57-8) → 2-benzyloxy-5-methoxybenzyl chloride (214072-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaBH₄ / methanol / 2 h / 20 °C

2: 86 percent / SOCl₂; pyridine / benzene; CH₂Cl₂ / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane; benzene;

DOI:10.1021/jm0581718

Reference yield: 73.0%

2-benzyloxy-5-methoxybenzyl chloride (214072-74-9) + ethyl acetoacetate (141-97-9) → ethyl 2-(2-benzyloxy-5-methoxy)benzyl-3-oxobutanoate (118237-06-2)

Guidance literature:

ethyl acetoacetate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2.5h;

2-benzyloxy-5-methoxybenzyl chloride; In tetrahydrofuran; Heating;

DOI:10.1021/jm0581718

upstream raw materials:

(2-(benzyloxy)-5-methoxyphenyl)methanol

2-benzyloxy-5-methoxybenzaldehyde

Downstream raw materials:

ethyl 2-(2-benzyloxy-5-methoxy)benzyl-3-oxobutanoate

2,4-diamino-5-methyl-6-(2-hydroxy-5-methoxybenzyl)pyrido [2,3-d ]pyrimidine

2,4-diamino-5-methyl-6-(2'-benzyloxy-5'-methoxybenzyl)-7-chloropyrid[2,3-d]pyrimidine

2,4-diamino-5-methyl-6-(2'-benzyloxy-5'-methoxybenzyl)pyrido[2,3-d]pyrimidin-7(8H)-one