[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

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Chemical Name:[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester
CAS No.:203259-18-1
Molecular Formula:C₃₉H₄₁NO₇
Molecular Weight:635.757
Hs Code.:

Synonyms:[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

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Chemical Property of [(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

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Technology Process of [(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

There total 8 articles about [(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 203259-13-6
(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-3-tert-butoxycarbonylmethyl-2,3-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

: 203259-18-1
[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00377-9

Reference yield:

: 934-00-9
3-methocycatechol

: 203259-18-1
[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NBS / acetic acid / Ambient temperature

2: K₂CO₃ / dimethylformamide / Ambient temperature

3: n-BuLi / tetrahydrofuran / -78 - 0 °C

4: NH₄Cl

5: 67 percent / aq. Na₂CO₃, LiCl / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / Heating

6: 78 percent / NaBH₄ / methanol / 0 °C

With sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; sodium carbonate; potassium carbonate; ammonium chloride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10641-4

Reference yield:

: 203259-23-8
2,3-dibenzyloxy-4-methoxy-1-bromobenzene

: 203259-18-1
[(2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi / tetrahydrofuran / -78 - 0 °C

2: NH₄Cl

3: 67 percent / aq. Na₂CO₃, LiCl / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / Heating

4: 78 percent / NaBH₄ / methanol / 0 °C

With sodium tetrahydroborate; n-butyllithium; sodium carbonate; ammonium chloride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(97)10641-4