5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate>

Base Information

• Chemical Name: 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate>
• CAS No.: 78512-47-7
• Molecular Formula: C₃₆H₃₉N₄O₈PS₂
• Molecular Weight: 750.833
• Mol file: 78512-47-7.mol

Synonyms:5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate>

Chemical Property of 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate>

There total 1 articles about 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Thiram (137-26-8,93196-73-7) + 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) + 2-Cyanoethyl phosphate (2212-88-6) → 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate> (78512-47-7)

Guidance literature:

With quinoline-8-sulfonyl chloride; triphenylphosphine; Yield given. Multistep reaction; 1.) pyridine, 12 h, 2.) 24 h, room temp.;

DOI:10.1021/jo00333a026

Reference yield:

5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate> (78512-47-7) → C33H35N3O8PS2(1-) (78512-49-9)

Guidance literature:

With triethylamine; In pyridine; at 25 ℃; for 6h;

DOI:10.1021/jo00333a026

Reference yield:

5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate> (78512-47-7) → C63H70N8O19P2S4 (78456-47-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 2percent Benzenesulfonic Acid / dioxane; methanol / 0.42 h / 0 °C

2: (8-Qinolinesulfonyl)tetrazole / pyridine / 1 h

3: Et₃N / pyridine / 6 h / 25 °C

4: (8-Quinolinesulfonyl)tetrazole / pyridine / 1 h / Ambient temperature

With (8-quinolinesulfonyl)tetrazole; 8-quinolinesulphonyl tetrazolide; triethylamine; benzenesulfonic acid; In 1,4-dioxane; pyridine; methanol;

DOI:10.1021/jo00333a026

upstream raw materials:

Thiram

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

2-Cyanoethyl phosphate

Downstream raw materials:

C₃₃H₃₅N₃O₈PS₂^(1-)

C₆₃H₇₀N₈O₁₉P₂S₄

C₄₆H₅₃N₆O₁₄P₂S₄^(1-)

C₄₉H₅₇N₇O₁₄P₂S₄