(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

Base Information

Chemical Name:(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane
CAS No.:183794-32-3
Molecular Formula:C₂₆H₃₇NO₃Si
Molecular Weight:439.67
Hs Code.:

Synonyms:(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

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Chemical Property of (2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

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Technology Process of (2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

There total 8 articles about (2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 183794-31-2
Methanesulfonic acid (S)-2-[(3R,5S)-5-(4-benzyloxy-benzyl)-morpholin-3-yl]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl ester

: 183794-32-3
(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

Guidance literature:: With triethylamine; In acetonitrile; for 10h; Heating;
DOI:10.1021/jo961114p

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 183794-32-3
(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / collidine / CH₂Cl₂ / 1.25 h

2: 79 percent / triethylamine / acetonitrile / 10 h / Heating

With 2,3,5-trimethyl-pyridine; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo961114p

Reference yield:

: 183794-28-7
{(2R,3S)-3-[(S)-2-Amino-3-(4-benzyloxy-phenyl)-propoxymethyl]-oxiranyl}-methanol

: 183794-32-3
(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / dioxane / 9 h / Heating

2: 80 percent / triethylamine / CH₂Cl₂ / 1.17 h

3: 99 percent / collidine / CH₂Cl₂ / 1.25 h

4: 79 percent / triethylamine / acetonitrile / 10 h / Heating

With 2,3,5-trimethyl-pyridine; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo961114p