6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

Base Information

Chemical Name:6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate
CAS No.:1235840-93-3
Molecular Formula:C₂HF₃O₂*C₂₂H₂₁F₄N₅O
Molecular Weight:561.459
Hs Code.:

Synonyms:6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

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Chemical Property of 6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

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Technology Process of 6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

There total 1 articles about 6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235842-52-0
tert-butyl 4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)-4-fluoropiperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1235840-93-3
6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

Guidance literature:: In dichloromethane; acetonitrile; at 20 ℃; for 0.166667h;

Reference yield:

: 1235840-93-3
6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 1235840-98-8
6-(4-(2-(1-(2-dimethylamino-2-oxoethyl)-4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: 6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate; 2-chloro-N,N-dimethylacetamide; With N-ethyl-N,N-diisopropylamine; In methanol; at 55 ℃; for 0.333333h;

With ammonia; In methanol; at 20 ℃; for 1h;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1235840-93-3
6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1235841-10-7
6-(4-(2-(4-fluoro-1-methyl-piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitril trifluoroacetate

Guidance literature:: formaldehyd; 6-(4-(2-(4-fluoropiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate; With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; acetonitrile; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;

trifluoroacetic acid; Acidic prep HPLC;