(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Base Information

Chemical Name:(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea
CAS No.:1450733-44-4
Molecular Formula:C₂₄H₃₃N₃O₄
Molecular Weight:427.544
Hs Code.:

Synonyms:(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Suppliers and Price of (S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

There total 12 articles about (S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1450733-41-1
(S)-1-benzyl-3-(1-(p-(tert-butyldimethylsilyloxy)benzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 1450733-44-4
(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 1450733-44-4
(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 2.67 h / -78 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / 12 h / 20 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C

6.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

7.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

7.2: 24 h / 20 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With 1H-imidazole; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 1450733-33-1
(S)-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)carbamic acid benzyl ester

: 1450733-44-4
(S)-1-benzyl-3-(1-(4-hydroxybenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C

3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With 1H-imidazole; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; methyl iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018