2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Chemical Name:2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione
CAS No.:1262512-76-4
Molecular Formula:C₂₂H₂₁ClO₃S
Molecular Weight:400.926
Hs Code.:

Synonyms:2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Chemical Property of 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Technology Process of 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

There total 6 articles about 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262512-74-2
2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone

: 1262512-76-4
2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: With hydrogenchloride; water; In acetone; at 120 ℃; for 1h; microwave irradiation;

Reference yield:

: 24680-29-3
[5-(4-chloro-phenyl)-thiophen-2-yl]-methanol

: 1262512-76-4
2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: 1-butyl-3-methylimidazolium trifluoromethanesulfonimide / 1,2-dimethoxyethane / 0.5 h / 180 °C / microwave irradiation

3.1: potassium carbonate / acetone / 6 h / 40 °C

4.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation

With hydrogenchloride; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; ethylbenzene; acetone;

Reference yield:

: 38401-71-7
5-(4-chlorophenyl)thiophene-2-carboxaldehyde

: 1262512-76-4
2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

1.2: 0.08 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: 1-butyl-3-methylimidazolium trifluoromethanesulfonimide / 1,2-dimethoxyethane / 0.5 h / 180 °C / microwave irradiation

4.1: potassium carbonate / acetone / 6 h / 40 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation

With hydrogenchloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; n-heptane; ethylbenzene; acetone;