24680-29-3

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 40877-09-6 4-chloro-1-(4-chlorophenyl)butan-1-one 
• 108-90-7 chlorobenzene 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 649569-56-2 methyl 5-(4-chlorophenyl)thiophene-2-carboxylate 

Downstream Products

• 24680-30-6 2-Chloromethyl-5-(4-chloro-phenyl)-thiophene 
• 1262512-78-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-5-(tetrahydro-furan-3-ylmethyl)cyclopent-2-enone 
• 1262511-91-0 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-(tetrahydro-furan-3-ylmethyl)cyclopentane-1,3-dione 
• 1262512-70-8 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]cyclopentane-1,3-dione 
• 1262512-72-0 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-cyclopent-2-enone 
• 1262512-74-2 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone 
• 1262512-76-4 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262511-89-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-(tetrahydro-pyran-4-ylmethyl)cyclopentane-1,3-dione 
• 1262512-68-4 3-[5-(4-chloro-phenyl)thiophen-2-ylmethoxy]cyclopent-2-enone 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 1361312-08-4 2-(4-chlorophenyl)-5-(3-methyl-2-butenyloxy)methylthiophene 
• 147380-64-1 N-hydroxy-N-[2-(5-(4-chlorophenyl)thien-2-ylmethoxy)ethyl] urea 
• 24680-31-7 2-(5-(4-chlorophenyl)thiophen-2-yl)acetonitrile 
• 84863-77-4 [5-(4-Chloro-phenyl)-thiophen-2-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Pyrimidinone compounds

Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.