Technology Process of (1S,2R)-1-phenyl-2-acetyl-N,N-diethylcyclopropanecarboxamide
There total 4 articles about (1S,2R)-1-phenyl-2-acetyl-N,N-diethylcyclopropanecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate; 4 A molecular sieve;
In
dichloromethane;
for 2h;
Ambient temperature;
DOI:10.1021/jo9518056
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BuLi / 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h
2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1) CH2Cl2, -78 deg C, 2 h; 2) CH2Cl2, -78 deg C, 1 h
3: 93 percent / tetrahydrofuran / 2 h / -20 °C
4: 94 percent / PDC, molecular sieves 4 Angstroem / CH2Cl2 / 2 h / Ambient temperature
With
dipyridinium dichromate; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9518056
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1) CH2Cl2, -78 deg C, 2 h; 2) CH2Cl2, -78 deg C, 1 h
2: 93 percent / tetrahydrofuran / 2 h / -20 °C
3: 94 percent / PDC, molecular sieves 4 Angstroem / CH2Cl2 / 2 h / Ambient temperature
With
dipyridinium dichromate; oxalyl dichloride; 4 A molecular sieve; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9518056