(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Base Information

• Chemical Name: (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane
• CAS No.: 102389-99-1
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Mol file: 102389-99-1.mol

Synonyms:(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Chemical Property of (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

There total 6 articles about (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(+)-(2S,3R)-1-chlorooctane-2,3-diol + benzyl bromide (100-39-0) → (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane (102389-99-1)

Guidance literature:

(+)-(2S,3R)-1-chlorooctane-2,3-diol; With sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00399

Reference yield:

Toluene-4-sulfonic acid (2R,3R)-3-benzyloxy-2-hydroxy-octyl ester → (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane (102389-99-1)

Guidance literature:

With sodium hydroxide; In methanol; Yield given;

DOI:10.1039/c39850001636

Reference yield:

benzyl bromide (100-39-0) → (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane (102389-99-1)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH

2: aq. HCl

3: pyridine

4: NaOH / methanol

With pyridine; hydrogenchloride; sodium hydroxide; sodium hydride; In methanol;

DOI:10.1039/c39850001636

upstream raw materials:

benzyl bromide

(E)-1-chlorooct-2-ene