(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Base Information

Chemical Name:(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane
CAS No.:102389-99-1
Molecular Formula:C₁₅H₂₂O₂
Molecular Weight:234.338
Hs Code.:

Synonyms:(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

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Chemical Property of (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

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Technology Process of (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

There total 6 articles about (+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (+)-(2S,3R)-1-chlorooctane-2,3-diol

: 100-39-0
benzyl bromide

: 102389-99-1
(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Guidance literature:: (+)-(2S,3R)-1-chlorooctane-2,3-diol; With sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.joc.5b00399

Reference yield:

: Toluene-4-sulfonic acid (2R,3R)-3-benzyloxy-2-hydroxy-octyl ester

: 102389-99-1
(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Guidance literature:: With sodium hydroxide; In methanol; Yield given;
DOI:10.1039/c39850001636

Reference yield:

: 100-39-0
benzyl bromide

: 102389-99-1
(+)-(2R,3R)-3-benzyloxy-1,2-epoxyoctane

Guidance literature:: Multi-step reaction with 4 steps

1: NaH

2: aq. HCl

3: pyridine

4: NaOH / methanol

With pyridine; hydrogenchloride; sodium hydroxide; sodium hydride; In methanol;
DOI:10.1039/c39850001636