N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

Base Information

Chemical Name:N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide
CAS No.:1026557-83-4
Molecular Formula:C₂₂H₂₂F₃N₃O₅S
Molecular Weight:497.495
Hs Code.:

<i>N</i>-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-<i>N</i>-hydroxy-formamide

Synonyms:N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

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Chemical Property of N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

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Technology Process of N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

There total 4 articles about N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1026557-83-4
N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

2: aq. NaOH / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3 h / 90 °C

3: HONH₂*HCl; pyridine / ethanol; tetrahydrofuran / 16 h / 23 °C

4: BH₃*pyr; HCl / ethanol; tetrahydrofuran; dioxane / 5 h / 20 °C

5: tetrahydrofuran / 0.5 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; borane pyridine; hydroxylamine hydrochloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920

Reference yield:

: 220616-31-9
3-(3-bromo-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione

: 1026557-83-4
N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

2: aq. NaOH / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3 h / 90 °C

3: HONH₂*HCl; pyridine / ethanol; tetrahydrofuran / 16 h / 23 °C

4: BH₃*pyr; HCl / ethanol; tetrahydrofuran; dioxane / 5 h / 20 °C

5: tetrahydrofuran / 0.5 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; borane pyridine; hydroxylamine hydrochloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920

Reference yield:

: 220615-61-2
3-(3-(4-bromophenylsulfanyl)-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione

: 1026557-83-4
N-[2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethoxy-biphenyl-4-ylsulfanylmethyl)-ethyl]-N-hydroxy-formamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3 h / 90 °C

2: HONH₂*HCl; pyridine / ethanol; tetrahydrofuran / 16 h / 23 °C

3: BH₃*pyr; HCl / ethanol; tetrahydrofuran; dioxane / 5 h / 20 °C

4: tetrahydrofuran / 0.5 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; borane pyridine; hydroxylamine hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol;
DOI:10.1021/jm0103920