17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan

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Chemical Name:17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan
CAS No.:1192546-37-4
Molecular Formula:C₂₇H₂₉BrN₂O₄
Molecular Weight:525.442
Hs Code.:

Synonyms:17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan

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Technology Process of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan

There total 1 articles about 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 586-76-5
4-Bromobenzoic acid

: 67025-97-2
6β-naltrexamine

: 1192546-37-4
17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-bromo)benzamido]morphinan

Guidance literature:: 4-Bromobenzoic acid; 6β-naltrexamine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2009.07.069