{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

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Chemical Name:{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester
CAS No.:1446791-74-7
Molecular Formula:C₂₄H₃₂N₈O₃
Molecular Weight:480.57
Hs Code.:

Synonyms:{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

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Chemical Property of {(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

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Technology Process of {(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

There total 10 articles about {(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1446791-72-5
6-chloro-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazine-3-carboxylic acid amide

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1446791-74-7
{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 52h;

Reference yield:

: 1446791-69-0
1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamine

: 1446791-74-7
{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 48 h / 140 °C

2: ammonia / methanol / 2 h

3: 1-methyl-pyrrolidin-2-one / 52 h / 150 °C

With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;

Reference yield:

: 145901-11-7
6-amino-1H-pyrrolo<2,3-b>pyridine

: 1446791-74-7
{(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate / acetic acid / 3 h / 120 °C

2: caesium carbonate / acetonitrile / 16 h

3: hydrazine / ethanol / 16 h

4: acetonitrile / 48 h / 140 °C

5: ammonia / methanol / 2 h

6: 1-methyl-pyrrolidin-2-one / 52 h / 150 °C

With ammonia; sodium acetate; caesium carbonate; hydrazine; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetic acid; acetonitrile;