145901-11-7

Usage

Uses

Used in Organic Synthesis:
6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and reactivity contribute to the development of novel molecules with biological activity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE is utilized as a versatile intermediate for the creation of new compounds with potential therapeutic applications.
Used in Chemical Research and Development:
6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE is employed as an important compound in chemical research and development due to its nitro-group functionality, which provides opportunities for further derivatization and modification, enhancing its potential in various applications.

InChI:InChI=1/C7H7N3/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H3,8,9,10)

Upstream product

• 271-63-6 7-Azaindole 
• 141-86-6 2.6-diaminopyridine 
• 107-21-1 ethylene glycol 
• 55052-27-2 6-chloro-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 143468-13-7 6-Bromo-1H-pyrrolo<2,3-b>pyridine 

Downstream Products

• 1346447-43-5 tert-butyl 1H-pyrrolo[2,3-b]pyridin-6-ylcarbamate 
• 1446791-65-6 2-(1H-pyrrolo[2,3-b]pyridin-6-yl)isoindoline-1,3-dione 
• 1446790-54-0 6-((1R,2S)-2-amino-cyclohexylamino)-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446791-74-7 {(1S,2R)-2-[6-carbamoyl-5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-pyridazin-3-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester 
• 1446791-69-0 1-methyl-1H-pyrrolo[2,3-b]pyridin-6-ylamine 
• 1342811-68-0 N-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 

Relevant academic research and scientific papers

Functionalization of 1H-Pyrrolopyridine

Functionalization of 1H-pyrrolopyridine (7-azaindole) was studied to provide new compounds directing toward agrochemicals and/or functional materials.Amino groups such as NH2, NH(CH2)2NH2, and NH(CH2)2NH(CH2)2NH2 were introduced onto 6-position of

6-Amino-7-Azaindoles synthesis from 2,6-diamino pyridine and diols

6-Amino-7-azaindole has been prepared by combination of diaminopyridine and diols by means of an acceptorless dehydrogenative condensation. In addition, amino pyridines may also yield towards pyrrolo[3,2-b]pyrrole systems. All of these transformation have

Preparation method of drug composition for treating febrile convulsion in children

The invention relates to a preparation method of a drug composition for treating febrile convulsion in children. The method comprises a route as shown in the specification. A treatment mechanism of the drug of the invention is to prolong the convulsion latency of a febrile convulsion patient, shorten the convulsion duration, relieve the convulsion seriousness, inhibit apoptosis of hippocampal neurons, regulate the levels of GABA and Glu, relieve the cerebral injury of febrile convulsion patient and finally achieve the purpose of treating the febrile convulsion.

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

The aggregation of amyloid-β peptides into cytotoxic oligomeric and fibrillary aggregates is believed to be one of the major pathological events in Alzheimer disease. Here we report the design and synthesis of a novel series of indole and 7-azaindole derivatives containing, nitrile, piperidine and N-methyl-piperidine substituents at the 3-position to prevent the pathological self-assembly of amyloid-β. We have further demonstrated that substitution of the azaindole and indole derivatives at the 3 positions is required to obtain compounds with improved physicochemical properties to allow brain penetration.

Heterocyclic compounds

The present invention relates to a novel heterocyclic compound or to pharmaceutically acceptable salts and solvates thereof. The pharmaceutical composition or cosmetic composition comprising, as active ingredients, the compound or pharmaceutically acceptable salts and solvates thereof may be effectively used in the treatment or prevention of skin diseases.

PYRIDAZINE AMIDE COMPOUNDS

The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like prote

Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like prote

NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer?s disease, and of diseases or conditions associated with amyloid-like prote

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.