C₁₂H₁₄O₃

Base Information

Chemical Name:C₁₂H₁₄O₃
CAS No.:1449657-86-6
Molecular Formula:C₁₂H₁₄O₃
Molecular Weight:206.241
Hs Code.:

C<sub>12</sub>H<sub>14</sub>O<sub>3</sub>

Synonyms:C₁₂H₁₄O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₂H₁₄O₃

Chemical Property:

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Technology Process of C₁₂H₁₄O₃

There total 3 articles about C₁₂H₁₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 53560-33-1
3,4,5-trimethoxyphenylacetylene

: 74-88-4
methyl iodide

: 1449657-86-6
C₁₂H₁₄O₃

Guidance literature:: 3,4,5-trimethoxyphenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -40 - 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -40 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol4020464

Reference yield: 74.0%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 74-99-7
prop-1-yne

: 1449657-86-6
C₁₂H₁₄O₃

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c00413

Reference yield:

: 24313-88-0
3,4,5-Trimethoxyaniline

: 1449657-86-6
C₁₂H₁₄O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 1.33 h / 20 °C / Cooling with ice

2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction / 2.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.1c00413