3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

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Chemical Name:3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride
CAS No.:1055305-35-5
Molecular Formula:C₂₀H₂₀F₂N₄O₄S*ClH
Molecular Weight:486.927
Hs Code.:

Synonyms:3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

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Chemical Property of 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

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Technology Process of 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

There total 15 articles about 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1055307-03-3
tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

: 1055305-35-5
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; isopropyl alcohol; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055305-35-5
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

9.1: hydrogenchloride; isopropyl alcohol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055305-35-5
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)-N-(2-hydroxyethyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

2.2: 3 h / -78 °C

3.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

5.2: 0.17 h / 0 °C

5.3: 0.25 h / 0 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

6.2: 16 h / 65 °C

6.3: 0.17 h / 20 °C

7.1: tetrahydrofuran / 0.08 h / 20 °C

8.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

9.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

11.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

12.1: hydrogenchloride; isopropyl alcohol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide;