tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

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Chemical Name:tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate
CAS No.:1055307-03-3
Molecular Formula:C₂₅H₂₈F₂N₄O₆S
Molecular Weight:550.583
Hs Code.:

Synonyms:tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

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Chemical Property of tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

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Technology Process of tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

There total 16 articles about tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1055307-02-2
3-{[4-{[(tert-butoxycarbonyl)(methyl)amino]methyl}-3-fluoro-2-(2-fluoropyridin-3-yl)-1H-pyrrol-1-yl]sulfonyl}benzoic acid

: 141-43-5
ethanolamine

: 1055307-03-3
tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055307-03-3
tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 0.25 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

5.2: 16 h / 65 °C

5.3: 0.17 h / 20 °C

6.1: tetrahydrofuran / 0.08 h / 20 °C

7.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

8.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055307-03-3
tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(3-{[(2-hydroxyethyl)amino]carbonyl}phenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydroxide; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;