(S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Base Information

• Chemical Name: (S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester
• CAS No.: 1304143-55-2
• Molecular Formula: C₃₃H₄₅ClN₄O₄
• Molecular Weight: 597.198

Synonyms:(S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Chemical Property of (S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

There total 4 articles about (S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(x)C2HF3O2*C26H35ClN4O3 + Cyclohexanecarboxylic acid (98-89-5) → (S)-N2-(cyclohexanoyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-55-2)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1007/s10989-011-9246-z

Reference yield:

(S)-N2-(tert-butoxycarbonyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-54-1) → (S)-N2-(cyclohexanoyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 8 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane;

DOI:10.1007/s10989-011-9246-z

Reference yield:

4-(4-(3-chlorophenyl)-piperazin-1-yl)-butan-1-amine → (S)-N2-(cyclohexanoyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 8 h / 20 °C

2: dichloromethane / 1 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 8 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane;

DOI:10.1007/s10989-011-9246-z

upstream raw materials:

(S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Cyclohexanecarboxylic acid

Boc-Glu(OBzl)-OH

Downstream raw materials:

(S)-N-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}-1-(cyclohexanoyl)pyrrolidin-5-on-2-carboxamide

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