ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

Base Information

Chemical Name:ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate
CAS No.:1377411-51-2
Molecular Formula:C₁₉H₂₈O₅
Molecular Weight:336.428
Hs Code.:

Synonyms:ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

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Chemical Property of ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

Chemical Property:

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Technology Process of ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

There total 1 articles about ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1377411-48-7
ethyl (S)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2,2-dimethylpropanoate

: 100-39-0
benzyl bromide

: 1377411-51-2
ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

Guidance literature:: ethyl (S)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2,2-dimethylpropanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;
DOI:10.1055/s-0031-1290489

Reference yield: 99.0%

: 1377411-51-2
ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

: 895532-73-7
(S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 4h;
DOI:10.1055/s-0031-1290489

Reference yield:

: 1377411-51-2
ethyl (S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropanoate

: 79-50-5,599-04-2,5405-40-3,52126-90-6
(S)-pantolactone

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 4 h / 0 °C

2.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

2.2: 12 h / 20 °C

3.1: acetic acid / 24 h / 20 °C

4.1: sodium periodate / methanol; water / 2 h

5.1: sodium dihydrogenphosphate; sodium chlorite / methanol; dichloromethane; water / 4 h / 20 °C

6.1: potassium carbonate / methanol / 6 h / 20 °C

6.2: 1 h

7.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h

With dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1055/s-0031-1290489