5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Base Information

Chemical Name:5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide
CAS No.:1383988-47-3
Molecular Formula:C₂₅H₁₇F₂N₅O₃S
Molecular Weight:505.504
Hs Code.:

Synonyms:5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

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Chemical Property of 5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

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Technology Process of 5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

There total 2 articles about 5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.39%

: 1083326-30-0
N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

: 223704-97-0
2-amino-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383988-47-3
5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 3h;

Reference yield:

: 1083326-16-2
5-bromo-N-(2,4-difluorophenyl)pyridine-3-sulphonamide

: 1383988-47-3
5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / Heating; Sealed tube

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 80 °C

With potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;