N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

Base Information

Chemical Name:N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide
CAS No.:1255869-45-4
Molecular Formula:C₁₈H₁₈FN₃O₂S
Molecular Weight:359.424
Hs Code.:

Synonyms:N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

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Chemical Property of N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

Chemical Property:

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Technology Process of N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

There total 3 articles about N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1520-70-3
Ethanesulfonamide

: 1255870-88-2
2-fluoro-4-(5-formyl-pyridin-3-yl)-benzonitrile

: 23719-80-4
cyclopropylmagnesium bromide

: 1255869-45-4
N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

Guidance literature:: Ethanesulfonamide; 2-fluoro-4-(5-formyl-pyridin-3-yl)-benzonitrile; With titanium(IV) isopropylate; In toluene; for 2h; Reflux;

cyclopropylmagnesium bromide; In tetrahydrofuran; at -40 - -36 ℃; for 1h;

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1255869-45-4
N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 3 h / 95 °C

2.1: titanium(IV) isopropylate / toluene / 2 h / Reflux

2.2: 1 h / -40 - -36 °C

With titanium(IV) isopropylate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 113118-81-3
5-bromopyridine-3-carbaldehyde

: 1255869-45-4
N-((5-(4-cyano-3-fluorophenyl)pyridin-3-yl)(cyclopropyl)-methyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 3 h / 95 °C

2.1: titanium(IV) isopropylate / toluene / 2 h / Reflux

2.2: 1 h / -40 - -36 °C

With titanium(IV) isopropylate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; toluene;