2-chloro-6-fluoro-4-methylbenzaldehyde

Base Information

• Chemical Name: 2-chloro-6-fluoro-4-methylbenzaldehyde
• CAS No.: 1534389-88-2
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.586

Synonyms:2-chloro-6-fluoro-4-methylbenzaldehyde

Chemical Property of 2-chloro-6-fluoro-4-methylbenzaldehyde

Chemical Property:

• Boiling Point: 232.4±35.0 °C(Predicted)
• Density: 1.292±0.06 g/cm3(Predicted)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-chloro-6-fluoro-4-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-chloro-6-fluoro-4-methylbenzaldehyde

There total 3 articles about 2-chloro-6-fluoro-4-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-chloro-4-methyl-benzaldehyde (50817-80-6) → 2-chloro-6-fluoro-4-methylbenzaldehyde (1534389-88-2)

Guidance literature:

With 4-aminobenzene-1,3-disulfonic acid; palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; at 110 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1021/jacs.8b00048

Reference yield:

4-morpholinecarboxaldehyde (4394-85-8) + 1-chloro-3-fluoro-5-methylbenzene (93857-90-0) → 2-chloro-6-fluoro-4-methylbenzaldehyde (1534389-88-2)

Guidance literature:

1-chloro-3-fluoro-5-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h; Inert atmosphere;

4-morpholinecarboxaldehyde; In tetrahydrofuran; hexane; at -70 - 27 ℃; for 1.17h;

Reference yield:

1-chloro-3-fluoro-5-methylbenzene (93857-90-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-6-fluoro-4-methylbenzaldehyde (1534389-88-2)

Guidance literature:

1-chloro-3-fluoro-5-methylbenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.25h;

upstream raw materials:

4-morpholinecarboxaldehyde

1-chloro-3-fluoro-5-methylbenzene

N,N-dimethyl-formamide

2-chloro-4-methyl-benzaldehyde

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