2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Base Information

Chemical Name:2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol
CAS No.:875120-90-4
Molecular Formula:C₃₃H₃₂N₂O₄
Molecular Weight:520.628
Hs Code.:

Synonyms:2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

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Chemical Property of 2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

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Technology Process of 2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

There total 3 articles about 2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 875120-87-9
tert-butyl (2-(hydroxymethyl)-5-methoxyphenyl)carbonate

: 663957-14-0
benzyl-[4-(2-benzyloxy-benzyl)-oxazol-2-yl]-methyl-amine

: benzyl-[3a-(2-benzyloxy-benzyl)-6-methoxy-9,9a-dihydro-3aH-chromeno[2,3-d]oxazol-2-yl]-methyl-amine

: 875120-90-4
2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: With tert-butylmagnesium bromide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tetlet.2005.10.168

Reference yield:

: 875120-86-8
tert-butyl (2-formyl-5-methoxyphenyl)carbonate

: 875120-90-4
2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.02 h / 0 °C

2: 55 percent / tert-butyl magnesium bromide / tetrahydrofuran / -78 °C

With sodium tetrahydroborate; tert-butylmagnesium bromide; In tetrahydrofuran; water;
DOI:10.1016/j.tetlet.2005.10.168

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 875120-90-4
2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DMAP / tetrahydrofuran / 20 °C

2: 71 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.02 h / 0 °C

3: 55 percent / tert-butyl magnesium bromide / tetrahydrofuran / -78 °C

With dmap; sodium tetrahydroborate; tert-butylmagnesium bromide; In tetrahydrofuran; water;
DOI:10.1016/j.tetlet.2005.10.168