2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Base Information

Chemical Name:2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol
CAS No.:875120-97-1
Molecular Formula:C₂₆H₂₆N₂O₄
Molecular Weight:430.503
Hs Code.:

Synonyms:2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

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Chemical Property of 2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

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Technology Process of 2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

There total 4 articles about 2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 875120-90-4
2-[2-(benzyl-methyl-amino)-4-(2-benzyloxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

: 2-[(3aS,9aR)-2-(Benzyl-methyl-amino)-6-methoxy-9,9a-dihydro-chromeno[2,3-d]oxazol-3a-ylmethyl]-phenol

: 875120-97-1
2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: With palladium hydroxide - carbon; hydrogen; In methanol; under 760 Torr;
DOI:10.1016/j.tetlet.2005.10.168

Reference yield:

: 875120-86-8
tert-butyl (2-formyl-5-methoxyphenyl)carbonate

: 875120-97-1
2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.02 h / 0 °C

2: 55 percent / tert-butyl magnesium bromide / tetrahydrofuran / -78 °C

3: 31 percent / hydrogen; Pd(OH)2 on carbon / methanol / 760 Torr

With sodium tetrahydroborate; palladium hydroxide - carbon; tert-butylmagnesium bromide; hydrogen; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.tetlet.2005.10.168

Reference yield:

: 875120-87-9
tert-butyl (2-(hydroxymethyl)-5-methoxyphenyl)carbonate

: 875120-97-1
2-[2-(Benzyl-methyl-amino)-4-(2-hydroxy-benzyl)-oxazol-5-ylmethyl]-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / tert-butyl magnesium bromide / tetrahydrofuran / -78 °C

2: 31 percent / hydrogen; Pd(OH)2 on carbon / methanol / 760 Torr

With palladium hydroxide - carbon; tert-butylmagnesium bromide; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2005.10.168