tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Base Information

Chemical Name:tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate
CAS No.:889857-44-7
Molecular Formula:C₃₈H₄₆ClN₃O₉
Molecular Weight:724.251
Hs Code.:

Synonyms:tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Chemical Property of tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

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Technology Process of tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

There total 16 articles about tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-45-8
tert-butyl 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

: 889857-44-7
tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 889857-35-6
[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

: 889857-44-7
tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol / 2 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

4.1: CHIRALCEL OD-H / acetonitrile; trifluoroacetic acid / Resolution of racemate

5.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 20 °C

5.2: 1 h / -78 °C

6.1: triethylamine; dmap / N,N-dimethyl-formamide / 0 °C

With dmap; n-butyllithium; 2 % platinum on carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

: 889857-44-7
tert-butyl 3-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

3.1: CHIRALCEL OD-H / acetonitrile; trifluoroacetic acid / Resolution of racemate

4.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 20 °C

4.2: 1 h / -78 °C

5.1: triethylamine; dmap / N,N-dimethyl-formamide / 0 °C

With dmap; n-butyllithium; 2 % platinum on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;
DOI:10.1016/j.bmc.2013.04.079