2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Base Information

Chemical Name:2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide
CAS No.:177556-86-4
Molecular Formula:C₂₉H₂₈N₂O₄
Molecular Weight:468.552
Hs Code.:

Synonyms:2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

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Technology Process of 2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

There total 11 articles about 2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 177556-86-4
2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:

Reference yield: 43.8%

: 96-32-2
bromoacetic acid methyl ester

: 177556-81-9
2-(2-Cyclopropyl-8-hydroxy-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

: 177556-86-4
2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 177556-86-4
2-(8-(Carbomethoxymethyloxy)-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 56.6 percent / benzene / 4 h / Heating

2: 37.9 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

3: 55.8 percent / H₂ / 10percent Pd/C / ethyl acetate

4: 43.8 percent / NaH / dimethylformamide / Ambient temperature

With aluminium trichloride; borane; hydrogen; sodium hydride; tert-butylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q