Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)
CAS No.:774577-05-8
Molecular Formula:C₉H₁₇NO
Molecular Weight:155.24
Hs Code.:
Mol file:774577-05-8.mol

Synonyms:Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)

Suppliers and Price of Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)

Chemical Property:

PSA：23.47000
LogP:0.70740

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI)

There total 4 articles about Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1R,2R,4R,7S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (+/-)-anti-7-dimethylamino-bicyclo[2.2.1]heptan-2-one

: 774577-07-0,774577-05-8
(+/-)-anti-endo-7-dimethylamino-bicyclo[2.2.1]heptan-2-ol

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield:

: (-)-(1S,2S,4S)-2-exo-hydroxynorbornan-7-one oxime

: 774577-05-8,774577-07-0
(-)-(1S,2S,4S)-7-syn-dimethylaminonorbornan-2-exo-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaBH₄; NiCl₂*6H₂O / methanol / 12 h / -78 °C

1.2: NaBH₄; HCO₂H / methanol / 20 °C

2.1: formic acid; H₂O / 72 h / Heating

With sodium tetrahydroborate; nickel dichloride; In methanol; formic acid; water; 2.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.tetasy.2004.07.027

Reference yield:

: 5164-69-2,5164-70-5,89898-04-4,97858-70-3
(-)-(1R,2S,4S)-2-exo-hydroxynorbornan-7-one

: 774577-05-8,774577-07-0
(-)-(1S,2S,4S)-7-syn-dimethylaminonorbornan-2-exo-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NH₂OH*HCl; NaOAc / methanol / 5 h / 20 °C

2.1: NaBH₄; NiCl₂*6H₂O / methanol / 12 h / -78 °C

2.2: NaBH₄; HCO₂H / methanol / 20 °C

3.1: formic acid; H₂O / 72 h / Heating

With sodium tetrahydroborate; hydroxylamine hydrochloride; sodium acetate; nickel dichloride; In methanol; formic acid; water; 3.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.tetasy.2004.07.027