N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Base Information

Chemical Name:N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine
CAS No.:1384980-48-6
Molecular Formula:C₁₇H₁₉N₃O₄S
Molecular Weight:361.422
Hs Code.:

Synonyms:N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

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Technology Process of N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

There total 8 articles about N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 857771-08-5
2,2-dimethyl-3-(4-nitrophenyl)propanoic acid

: 76456-06-9
imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone

: 1384980-48-6
N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol301579q

Reference yield:

: 50818-24-1
2,2-dimethyl-3-(4-nitro-phenyl)-propionyl chloride

: 76456-06-9
imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone

: 1384980-48-6
N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Guidance literature:: imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

2,2-dimethyl-3-(4-nitro-phenyl)-propionyl chloride; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol301579q

Reference yield:

: 1384980-51-1
N-[2,2-dimethyl-3-phenylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

: 1384980-48-6
N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Guidance literature:: Multi-step reaction with 3 steps

1.1: [bis(acetoxy)iodo]benzene; palladium diacetate / acetic anhydride / 28 h / 70 °C

2.1: hydrogenchloride; water / 6 h / 50 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; [bis(acetoxy)iodo]benzene; water; palladium diacetate; triethylamine; In dichloromethane; acetic anhydride;
DOI:10.1021/ol301579q