Technology Process of De-A,B-22-benzenesulphonyl-24,25-diol-cholestan-8-benzyloxymethyl ether
There total 4 articles about De-A,B-22-benzenesulphonyl-24,25-diol-cholestan-8-benzyloxymethyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
De-A,B-22-benzenesulphonyl-23,24-dinorcholestan-8-benzyloxymethyl ether;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine;
In
tetrahydrofuran; hexane;
at -20 ℃;
for 0.25h;
2-(oxiran-2-yl)propan-2-ol;
In
tetrahydrofuran; hexane;
for 5h;
DOI:10.1016/S0039-128X(99)00110-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / Ph3P; imidazole; I2 / benzene / 3 h / 20 °C
2.1: 94 percent / dimethylformamide
3.1: 100 percent / Hunig's base / CH2Cl2 / 20 °C
4.1: diisopropylamine; tetramethylenediamine; n-BuLi / tetrahydrofuran; hexane / 0.25 h / -20 °C
4.2: 81 percent / tetrahydrofuran; hexane / 5 h
With
1H-imidazole; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; diisopropylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
1.1: Iodination / 2.1: sulfonylation / 3.1: Etherification / 4.1: Metallation / 4.2: Ring cleavage;
DOI:10.1016/S0039-128X(99)00110-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / dimethylformamide
2.1: 100 percent / Hunig's base / CH2Cl2 / 20 °C
3.1: diisopropylamine; tetramethylenediamine; n-BuLi / tetrahydrofuran; hexane / 0.25 h / -20 °C
3.2: 81 percent / tetrahydrofuran; hexane / 5 h
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
1.1: sulfonylation / 2.1: Etherification / 3.1: Metallation / 3.2: Ring cleavage;
DOI:10.1016/S0039-128X(99)00110-5
