1,2-Epoxy-3-hydroxy-3-methylbutane

Base Information

• Chemical Name: 1,2-Epoxy-3-hydroxy-3-methylbutane
• CAS No.: 19482-44-1
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.133
• European Community (EC) Number: 961-974-9
• Nikkaji Number: J634.171C
• Mol file: 19482-44-1.mol

Synonyms:2-(oxiran-2-yl)propan-2-ol;19482-44-1;1,2-epoxy-3-hydroxy-3-methylbutane;2-(2-OXIRANYL)-2-PROPANOL;SCHEMBL990066;EN300-1608690;Z1504677029

Chemical Property of 1,2-Epoxy-3-hydroxy-3-methylbutane

Chemical Property:

• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 102.068079557
• Heavy Atom Count: 7
• Complexity: 78.1

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C1CO1)O

Technology Process of 1,2-Epoxy-3-hydroxy-3-methylbutane

There total 2 articles about 1,2-Epoxy-3-hydroxy-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-methyl-but-2-ene (513-35-9) → 2-(oxiran-2-yl)propan-2-ol (19482-44-1) + 1-(2-methyl-oxiranyl)-ethanol (36688-49-0) + 2-methyl-3-buten-2-ol (115-18-4)

Guidance literature:

With titanium(IV) isopropylate; oxygen; 5,15,10,20-tetraphenylporphyrin; In dichloromethane; at 0 ℃; Irradiation;

DOI:10.1016/S0040-4039(00)84656-0

Reference yield:

2-methyl-but-2-ene (513-35-9) → 2-(oxiran-2-yl)propan-2-ol (19482-44-1) + 2-methyl-3-buten-2-ol (115-18-4) + 2-hydroperoxy-2-methyl-3-butene (15315-30-7) + acetone (67-64-1)

Guidance literature:

2-methyl-but-2-ene; With tert.-butylhydroperoxide; aluminum tri-tert-butoxide; In benzene; at 20 ℃; for 24h;

With sulfuric acid; In diethyl ether; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1023/A:1012357318443

Reference yield: 87.0%

2-(oxiran-2-yl)propan-2-ol (19482-44-1) + (R)-2-methoxy-4-methyl-1-(1-(phenylsulfonyl)propan-2-yl)benzene → (6R)-6-(2-methoxy-4-methylphenyl)-2-methyl-5-(phenylsulfonyl)heptane-2,3-diol

Guidance literature:

(R)-2-methoxy-4-methyl-1-(1-(phenylsulfonyl)propan-2-yl)benzene; With N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide; In tetrahydrofuran; at -50 ℃; Inert atmosphere;

2-(oxiran-2-yl)propan-2-ol; In tetrahydrofuran; at 0 ℃; for 5h; enantioselective reaction;

DOI:10.1016/j.tetasy.2014.10.016

upstream raw materials:

2-methyl-but-2-ene

Downstream raw materials:

(S)-5-Benzenesulfonyl-6-[(3S,9S,10R,13R,14R,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptane-2,3-diol

4-chloro-2-methylbutane-2,3-diol

De-A,B-22-benzenesulphonyl-24,25-diol-cholestan-8-benzyloxymethyl ether

1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol