1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

Base Information

Chemical Name:1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione
CAS No.:5040-13-1
Molecular Formula:C₂₂H₂₀N₂O₆
Molecular Weight:408.411
Hs Code.:

Synonyms:1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

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Chemical Property of 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

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Technology Process of 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

There total 2 articles about 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2235-01-0
dimethoxydiphenylmethane

: 58-96-8
uridine

: 5040-13-1
1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 50 ℃; for 24h;
DOI:10.1021/acs.joc.9b03425

Reference yield:

: 5040-13-1
1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: 3'-O-Trityl-uridin, NaH;

Reference yield:

: 5040-13-1
1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-diphenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

: (1S,3a′S,6′R,6a′R)-6′-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2′,2′-diphenyldihydro-6′H-spiro[cyclopropane-1,4′-furo[3,4-d]-[1,3]dioxol]-2-yl isobutyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / Reflux

2.1: potassium carbonate / acetonitrile / 3 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

4.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve

4.2: 16 h / 50 °C / Molecular sieve

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.joc.9b03425