2235-01-0

Basic information

• Product Name: BENZOPHENONE DIMETHYLKETAL
• Synonyms: [Dimethoxy(phenyl)methyl]benzene;Benzene, 1,1'-(dimethoxymethylene)bis-;BENZOPHENONE DIMETHYL ACETAL;BENZOPHENONE DIMETHYLKETAL;DIMETHOXYDIPHENYLMETHANE;Benzophenone dimethyl acetal, 98+%;Benzophenone dimethyl ketal, 98+%;Diphenyldimethoxymethane
• CAS NO: 2235-01-0
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.29
• EINECS: 218-788-1
• Mol File: 2235-01-0.mol
• Article Data: 38

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 290 °C
• Flash Point: 101.8 °C
• Appearance: /
• Density: 1.059 g/cm³
• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.542
• Sensitive: Moisture Sensitive
• BRN: 2051419
• CAS DataBase Reference: BENZOPHENONE DIMETHYLKETAL(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOPHENONE DIMETHYLKETAL(2235-01-0)
• EPA Substance Registry System: BENZOPHENONE DIMETHYLKETAL(2235-01-0)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 2235-01-0(Hazardous Substances Data)

Usage

General Description

Benzophenone dimethylketal is a chemical compound commonly used as a photoinitiator in the production of various industrial and consumer products, including coatings, adhesives, and inks. It acts as a catalyst to initiate the polymerization or crosslinking of certain materials when exposed to ultraviolet (UV) light, making it a crucial component in UV-curable systems. Benzophenone dimethylketal has also been utilized in the production of optical lenses, optical disks, and various electronic devices. However, there are concerns about its potential health and environmental effects, and its use is regulated in certain regions due to its reported toxicity and persistence in the environment.

InChI:InChI=1/C15H16O2/c1-16-15(17-2,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12H,1-2H3

Upstream product

• 5350-57-2 benzophenone hydrazone 
• 697-91-6 2,6-dichloro-1,4-benzoquinone 
• 908093-98-1 diazodiphenylmethane 
• 344443-97-6 α-methoxy-α-(methylthio)diphenylmethane 
• 67-56-1 methanol 
• 119-61-9 benzophenone 
• 149-73-5 trimethyl orthoformate 
• 530-48-3 1,1-Diphenylethylene 
• 616-42-2 dimethylsulfite 
• 681-84-5 tetramethylorthosilicate 
• 17421-82-8 diazido(diphenyl)methane 
• 2051-90-3 Dichlorodiphenylmethane 
• 3043-79-6 2-(diphenylmethylene)-N-phenylhydrazinecarboxamide 
• 100-47-0 benzonitrile 

Downstream Products

• 500564-30-7 5-bromomethyl-5-methyl-2,2-diphenyl-[1,3]dioxane 
• 599-67-7 1,1-diphenylethanol 
• 1016-09-7 benzhydryl methyl ether 
• 101-81-5 Diphenylmethane 
• 985-93-3 1,2-dimethoxy-1,1,2,2-tetraphenyl-ethane 
• 131866-04-1 (2,2-diphenyl-[1,3]dioxolan-4-yl)methanol 
• 7475-61-8 methoxy-diphenyl-acetic acid 
• 36728-56-0 N-(2-pyridinyl)benzophenone imine 
• 146499-09-4 (4R,5R)-2,2-diphenyl-1,3-dioxolane-4,5-dicarboxylic acid dimethyl ester 
• 144402-27-7 2-<(2S)-2,3-O-(diphenylmethylidene)-2,3-dihydroxypropyl>-1,3-dithiane 
• 144402-34-6 2-<(2R)-2,3-O-(diphenylmethylidene)-2,3-dihydroxypropyl>-1,3-dithiane 
• 220835-88-1 2,3:4,6-di-O-diphenylmethylene-α-D-glucopyranoside 
• 220835-89-2 methyl 2-O-diphenylmethoxymethyl-4,6-O-diphenylmethylene-α-D-glucopyranoside 
• 4360-65-0 4-bromomethyl-2,2-diphenyl-[1,3]dioxolane 

Relevant articles and documents

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity

A series of compounds generated by ring expansion/opening and molecular elongation/simplification of the 1,3-dioxolane scaffold were prepared and tested for binding affinity at 5-HT1AR and α1 adrenoceptors. The compounds with greater affinity were selected for further functional studies. N-((2,2-diphenyl-1,3-dioxan-5-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-ammonium hydrogen oxalate (12) emerged as highly potent full agonist at the 5-HT1AR (pKi 5-HT1A = 8.8; pD2 = 9.22, %Emax = 92). The pharmacokinetic data in rats showed that the orally administered 12 has a high biodistribution in the brain compartment. Thus, 12 was further investigated in-vivo, showing an anxiolytic and antidepressant effect. Moreover, in the formalin test, 12 was able to decrease the late response to the noxious stimulus, indicating a potential use in the treatment of chronic pain.

Silver-Catalyzed Olefination of Acetals and Ketals with Diazoesters to β-Alkoxyacrylates

The first silver-catalyzed reaction of acetals or ketals with diazoesters leading to trisubstituted or tetrasubstituted β-alkoxyacrylates is now reported. A broad range of acetals and ketals bearing different substituents is compatible with this protocol and thus provides an attractive approach for the synthesis of complex β-alkoxyacrylates. The power of this method was further demonstrated by the successful synthesis of picoxystrobin, which is one of the most popular agricultural fungicides commercialized by Dupont.

PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES

The present invention relates to an improved process for the preparation of 2- pyrimidine-5-boronic acid of formula (I). or salts or esters thereof.