2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester

Base Information

• Chemical Name: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester
• CAS No.: 147597-26-0
• Molecular Formula: C₁₉H₂₂N₂O₆
• Molecular Weight: 374.393
• Mol file: 147597-26-0.mol

Synonyms:2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester

Chemical Property of 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester

There total 4 articles about 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.7%

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-isobutyl ester (147597-19-1) → 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester (147597-26-0)

Guidance literature:

With sodium hydroxide; In acetone; for 2h; Ambient temperature;

DOI:10.1248/cpb.41.108

Reference yield:

isobutyl acetoacetate (7779-75-1) → 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester (147597-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 5 h / Heating

2: 63 percent / Bu₄NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1248/cpb.42.1579

Reference yield:

3-nitro-benzaldehyde (99-61-6) → 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monoisobutyl ester (147597-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 5 h / Heating

2: 63 percent / Bu₄NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1248/cpb.42.1579

upstream raw materials:

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-isobutyl ester

isobutyl acetoacetate

3-nitro-benzaldehyde

2-(3-nitrobenzylidene)-acetoacetic acid isobutylester