Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

Base Information

Chemical Name:Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester
CAS No.:616207-87-5
Molecular Formula:C₂₁H₂₈O₃
Molecular Weight:328.452
Hs Code.:

Synonyms:Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

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Technology Process of Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

There total 5 articles about Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 616207-86-4
(Z)-(4R,7S)-7-Benzyloxymethyl-5-methyl-nona-1,5-dien-4-ol

: 616207-87-5
Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.tetlet.2003.08.023

Reference yield:

: 916501-75-2
2-<(benzyloxy)-methyl>butyraldehyde

: 616207-87-5
Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran / 2 h / -78 - -20 °C

2: 96 percent / Dibal-H / CH₂Cl₂ / 1 h / -78 - -40 °C

3: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 1.5 h / 23 °C

4: diethyl ether / 3 h / -80 °C

5: 77 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

With sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Horner-Emmons reaction;
DOI:10.1016/j.tetlet.2003.08.023

Reference yield:

: 1025799-90-9
(Z)-(S)-4-Benzyloxymethyl-2-methyl-hex-2-enal

: 616207-87-5
Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 3 h / -80 °C

2: 77 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

With triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/j.tetlet.2003.08.023