(S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane

Base Information

• Chemical Name: (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane
• CAS No.: 215114-22-0
• Molecular Formula: C₁₂H₁₃F₃O₂S
• Molecular Weight: 278.295
• Mol file: 215114-22-0.mol

Synonyms:(S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane

Chemical Property of (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane

There total 1 articles about (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + ethyl trifluoroacetate, (383-63-1) + (+)-(R)-ethyl p-tolyl sulfoxide (1519-40-0) → 1-Methyl-4-((R)-(Z)-4,4,4-trifluoro-3-methoxy-but-2-ene-2-sulfinyl)-benzene + (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane (215114-22-0) + (S)-2-[(R)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane (215114-23-1) + (R)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane (215114-24-2)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4020(98)83043-3

Reference yield: 92.0%

(S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane (215114-22-0) → (S)-2-((S)-1-p-Tolylsulfanyl-ethyl)-2-trifluoromethyl-oxirane

Guidance literature:

With trifluoroacetic anhydride; sodium iodide; In acetone; at -20 ℃; for 0.333333h;

DOI:10.1016/S0040-4020(98)83043-3

Reference yield: 91.0%

benzylamine (100-46-9) + (S)-2-[(S)-1-((R)-Toluene-4-sulfinyl)-ethyl]-2-trifluoromethyl-oxirane (215114-22-0) → (2S,3S)-2-(Benzylamino-methyl)-1,1,1-trifluoro-3-((R)-toluene-4-sulfinyl)-butan-2-ol (215114-45-7)

Guidance literature:

In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(98)83043-3

upstream raw materials:

diazomethane

ethyl trifluoroacetate,

(+)-(R)-ethyl p-tolyl sulfoxide

Downstream raw materials:

(2S,3S)-2-(Benzylamino-methyl)-1,1,1-trifluoro-3-((R)-toluene-4-sulfinyl)-butan-2-ol

(2S,3S)-3-((R)-Toluene-4-sulfinyl)-2-trifluoromethyl-butane-1,2-diol

Benzoic acid (2S,3S)-2-hydroxy-3-p-tolylsulfanyl-2-trifluoromethyl-butyl ester

Benzoic acid (2S,3S)-2-hydroxy-3-((R)-toluene-4-sulfinyl)-2-trifluoromethyl-butyl ester