2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine

Base Information

• Chemical Name: 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine
• CAS No.: 1396037-06-1
• Molecular Formula: C₂₉H₃₆N₄O₅
• Molecular Weight: 520.629
• Mol file: 1396037-06-1.mol

Synonyms:2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine

Chemical Property of 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine

There total 4 articles about 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4,6-dimethyl-2-methoxypyrimidine (14001-61-7) + N,N-4-(dimethylamino)-3-(methoxymethyl)benzaldehyde (1236355-60-4) → 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine (1396037-06-1)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; Reflux;

DOI:10.1016/j.bmc.2012.06.045

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine (1396037-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water / 25 °C / Reflux

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / Reflux

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In water;

DOI:10.1016/j.bmc.2012.06.045

Reference yield:

N,N-4-(dimethylamino)-3-(methoxymethyl)benzoic acid methyl ester (1396038-73-5) → 2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine (1396037-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 20 °C

2.1: manganese(IV) oxide / dichloromethane / Reflux

3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / Reflux

With manganese(IV) oxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmc.2012.06.045

upstream raw materials:

4,6-dimethyl-2-methoxypyrimidine

N,N-4-(dimethylamino)-3-(methoxymethyl)benzaldehyde

N,N-4-(dimethylamino)-3-(methoxymethyl)benzoic acid methyl ester

N,N-4-(dimethylamino)-3-(methoxymethyl)benzyl alcohol

Downstream raw materials:

2-methoxy-(E,E)-4,6-bis-(3'-hydroxy-4'-N,N-dimethylaminostyryl)pyrimidine