2-methoxy-4,6-dimethylpyrimidine

Base Information

• Chemical Name: 2-methoxy-4,6-dimethylpyrimidine
• CAS No.: 14001-61-7
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.169
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID70465627
• Wikidata: Q72489741
• Mol file: 14001-61-7.mol

Synonyms:2-Methoxy-4,6-dimethylpyrimidine

Chemical Property of 2-methoxy-4,6-dimethylpyrimidine

Chemical Property:

• PSA: 35.01000
• LogP: 1.10200
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.8

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-4,6-dimethylpyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)OC)C

Technology Process of 2-methoxy-4,6-dimethylpyrimidine

There total 11 articles about 2-methoxy-4,6-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 2-chloro-4,6-dimethylpyrimidine (4472-44-0) → 4,6-dimethyl-2-methoxypyrimidine (14001-61-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 2h;

DOI:10.1007/s00706-015-1515-7

Reference yield: 70.0%

2-methyl-isourea (2440-60-0) + acetylacetone (123-54-6,81235-32-7) → 4,6-dimethyl-2-methoxypyrimidine (14001-61-7)

Guidance literature:

With potassium carbonate; In water; at 25 ℃; Reflux;

DOI:10.1016/j.bmc.2012.06.045

Reference yield: 1.0%

2-chloro-4,6-dimethylpyrimidine (4472-44-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4,6-dimethyl-2-methoxypyrimidine (14001-61-7) + 2-dimethylamino-4,6-dimethylpyrimidine (13012-25-4) + [(E)-2-(2-Chloro-6-methyl-pyrimidin-4-yl)-vinyl]-dimethyl-amine (179009-28-0)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Heating;

DOI:10.1002/jhet.5570330240

upstream raw materials:

methanol

sodium methylate

(4,6-dimethylpyrimid-2′-yl)-trimethylammonium chloride

2-chloro-4,6-dimethylpyrimidine

Downstream raw materials:

7-benzoylamino-1-methoxy-3-methyl-8H-pyrido<1,2-c>pyrimidin-8-one

2-methoxy-(E,E)-4,6-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)pyrimidine

2-methoxy-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine

2-methoxy-(E,E)-4,6-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)pyrimidine