4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

Base Information

Chemical Name:4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide
CAS No.:1245736-62-2
Molecular Formula:C₂₂H₁₉FN₄O₂S
Molecular Weight:422.483
Hs Code.:

Synonyms:4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

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Chemical Property of 4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

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Technology Process of 4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

There total 4 articles about 4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 402718-52-9
4-cyano-2-methylphenyl isothiocyanate

: 915087-26-2
4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide

: 1245736-62-2
4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

Guidance literature:: 4-cyano-2-methylphenyl isothiocyanate; 4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Microwave irradiation;

With water; hydrogenchloride; In ethanol; N,N-dimethyl-formamide; for 1h; Reflux;

Reference yield:

: 915087-25-1
2-fluoro-N-methyl-4-amino-benzamide

: 1245736-62-2
4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 24 h / 80 °C

2.1: N,N-dimethyl-formamide / 12 h / 110 °C / Microwave irradiation

2.2: 1 h / Reflux

With acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1245736-62-2
4-[7-(4-cyano-2-methyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / -5 °C

1.2: 0 - 25 °C

2.1: acetic acid / iron / ethyl acetate / Reflux

3.1: acetic acid / 24 h / 80 °C

4.1: N,N-dimethyl-formamide / 12 h / 110 °C / Microwave irradiation

4.2: 1 h / Reflux

With thionyl chloride; acetic acid; iron; In ethyl acetate; N,N-dimethyl-formamide;