Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine

Base Information

• Chemical Name: Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine
• CAS No.: 109960-57-8
• Molecular Formula: C₁₅H₂₄N₂
• Molecular Weight: 232.369
• Mol file: 109960-57-8.mol

Synonyms:Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine

Chemical Property of Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine

There total 6 articles about Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethylamine (75-04-7,85404-22-4) + (S)-3-Chloromethyl-1-((R)-1-phenyl-ethyl)-pyrrolidine; hydrochloride → Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine (109960-57-8)

Guidance literature:

In water; at 100 ℃; for 24h;

DOI:10.1021/jm00393a004

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine (109960-57-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 25 percent / 4A sieves / toluene / Ambient temperature

2: 51 percent / LiAlH / tetrahydrofuran / 24 h / Heating

3: 94 percent / SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

4: 94 percent / H₂O / 24 h / 100 °C

With thionyl chloride; 4 A molecular sieve; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene;

DOI:10.1021/jm00393a004

Reference yield:

(3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid (915302-94-2,96449-93-3,99735-44-1) → Ethyl-[(R)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine (109960-57-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 16 percent / p-TsOH / 24 h / Heating

2: 51 percent / LiAlH / tetrahydrofuran / 24 h / Heating

3: 94 percent / SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

4: 94 percent / H₂O / 24 h / 100 °C

With thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; water; 1,2-dichloro-ethane;

DOI:10.1021/jm00393a004

upstream raw materials:

ethylamine

(S)-1-phenyl-ethylamine

(3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid

(3S)-N-<(R)-phenylethyl>-3-(hydroxymethyl)pyrrolidine