3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester

Base Information

• Chemical Name: 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester
• CAS No.: 1235567-12-0
• Molecular Formula: C₁₆H₁₃F₃O₈S₂
• Molecular Weight: 454.402
• Mol file: 1235567-12-0.mol

Synonyms:3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester

Chemical Property of 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester

There total 2 articles about 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester (752242-45-8) + trifluoromethylsulfonic anhydride (358-23-6) → 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester (1235567-12-0)

Guidance literature:

With triethylamine; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1016/j.bmc.2014.02.009

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → 3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester (1235567-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 180 °C

2: triethylamine / dichloromethane / 2 h / -78 °C

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.02.009

Reference yield: 91.0%

3-(4-methanesulfonylphenoxy)-5-trifluoromethanesulfonyloxybenzoic acid methyl ester (1235567-12-0) + bis(pinacol)diborane (73183-34-3) → 3-(4-methanesulfonylphenoxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester (1235567-13-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 20 - 85 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.009

upstream raw materials:

3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester

trifluoromethylsulfonic anhydride

1-carbomethoxy-3,5-dihydroxybenzene

Downstream raw materials:

3-(4-methanesulfonylphenoxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester

3-(4-methanesulfonylphenoxy)-5-(3-methylpyridin-2-yl)benzoic acid methyl ester

3-(4-methanesulfonylphenoxy)-5-(3-methylpyridin-2-yl)benzoic acid

{2-[3-(4-methanesulfonylphenoxy)-5-(3-methylpyridine-2-yl)benzoylamino]thiazol-4-yl}acetic acid