Technology Process of SY586-170.1
There total 15 articles about SY586-170.1 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C34H42O11; (4R,5R)-3-(tert-butoxycarbonyl)-4-isobutyl-2-aryloxazolidine-5-carboxylic acid;
With
4-methyl-morpholine; dmap; pivaloyl chloride;
In
tetrahydrofuran;
at 38 ℃;
for 1h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; methanol;
at 2 ℃;
pH=1.5 - 1.9;
- Guidance literature:
-
C55H71NO17;
With
hydrogenchloride;
In
tetrahydrofuran; methanol;
at 2 ℃;
for 2h;
pH=1.5 - 1.9;
With
water; sodium hydrogencarbonate;
In
tetrahydrofuran; 4-methyl-morpholine; methanol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine; copper dichloride / ethyl acetate; ethanol / -13 - -1.3 °C / Inert atmosphere
1.2: 0.25 h
2.1: pyridine / -20 - 5.8 °C / Inert atmosphere
2.2: -17.5 - 20 °C
3.1: lithium borohydride / ethanol; tetrahydrofuran / -12 - 15 °C / Inert atmosphere
3.2: -10.8 - -3 °C
4.1: dmap; triethylamine / Isopropyl acetate / 3 h / 35 °C / Inert atmosphere
4.2: 0.25 h / 19.7 °C
5.1: water / acetic acid / methanol / 9 h / 50 - 55 °C
6.1: trifluoroacetic acid / toluene / -15 °C
6.2: 0.25 h / 5 °C / pH > 5
7.1: dmap; pivaloyl chloride; 4-methyl-morpholine / tetrahydrofuran / 38 °C / Inert atmosphere
8.1: hydrogenchloride / tetrahydrofuran; methanol / 2 h / 2 °C / pH 1.5 - 1.9
With
4-methyl-morpholine; pyridine; hydrogenchloride; dmap; lithium borohydride; water; pivaloyl chloride; triethylamine; trifluoroacetic acid; copper dichloride;
acetic acid;
In
tetrahydrofuran; methanol; ethanol; Isopropyl acetate; ethyl acetate; toluene;
