7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III

Base Information

Chemical Name:7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III
CAS No.:651293-82-2
Molecular Formula:C₄₁H₆₂O₁₀Si₂
Molecular Weight:771.108
Hs Code.:
Mol file:651293-82-2.mol

Synonyms:7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III

Suppliers and Price of 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxoBaccatinIII
2.5mg
$ 275.00

Medical Isotopes, Inc.
7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxoBaccatinIII
25 mg
$ 3000.00

Medical Isotopes, Inc.
7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxoBaccatinIII
2.5 mg
$ 750.00

Total 1 raw suppliers

Chemical Property of 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III

Chemical Property:

Storage Temp.:Refrigerator
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxoBaccatinIII ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 10-Deacetylbaccatin III (D198250) derivative, 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III is used in the preparation of taxane derivatives with antitumoral and antineoplastic properties.

Technology Process of 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III

There total 2 articles about 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 92950-45-3
10-dehydro 10-deacetyl 7-epibaccatin V

: 651293-82-2
7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III

Guidance literature:: 10-dehydro 10-deacetyl 7-epibaccatin V; With pyridine; In ethyl acetate; toluene; at -20 - 40 ℃; for 1h;

triethylsilyl trifluoromethyl sulfonate; In ethyl acetate; toluene; at -10 - -5.8 ℃; for 2h;

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 651293-82-2
7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Cu(OAc)2*H₂O; air / methanol / 72 h

2: 3 percent / imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; copper diacetate; air; In methanol; dichloromethane;
DOI:10.1002/ejoc.200300376

Reference yield: 72.4%

: 651293-82-2
7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III

: 943239-53-0
C₄₁H₆₆O₁₀Si₂

Guidance literature:: 7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III; With lithium borohydride; ethanol; In tetrahydrofuran; at -13.9 - 23 ℃;

With ammonium acetate; acetic acid; In tetrahydrofuran; ethanol; at 2.5 ℃; Product distribution / selectivity;