(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

Base Information

Chemical Name:(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride
CAS No.:1399845-07-8
Molecular Formula:C₁₄H₁₃BrN₄*ClH
Molecular Weight:353.649
Hs Code.:

Synonyms:(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

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Technology Process of (3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

There total 3 articles about (3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256389-39-5
(2S,4R)-2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1399845-07-8
(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 1399845-06-7
(2S,4R)-4-cyano-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

: 1399845-07-8
(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; ammonium acetate; In 1,4-dioxane; dichloromethane; xylene;

Reference yield:

: 273221-94-6
(2S,4R)-4-cyano-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 1399845-07-8
(3R,5S)-5-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-3-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C

2: ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile; xylene;