BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

Base Information

• Chemical Name: BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-
• CAS No.: 1054543-47-3
• Molecular Formula: C₃₃H₂₅F₆N₃O₃
• Molecular Weight: 625.57
• Mol file: 1054543-47-3.mol

Synonyms:4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide

Chemical Property of BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

Chemical Property:

• Melting Point: 225-228°C
• Boiling Point: 703.5±70.0 °C(Predicted)
• PKA: 15.98±0.50(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: +2C to +8C
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Apoptozole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

• Uses: Apoptozoleis an inhibitor of heat shock protein 70 (Hsp70) and acts by blocking its ATPase activity. Induces apoptosis in cancer cells.

Technology Process of BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

There total 5 articles about BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-(3,5-bis(trifluoromethyl)phenyl)-4,5-di(4-methoxyphenyl)-1H-imidazole + 4-(bromomethyl)benzamide (58914-40-2) → 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide (1054543-47-3)

Guidance literature:

With ammonium acetate; acetic acid; at 150 ℃; Microwave irradiation; Inert atmosphere;

DOI:10.1039/c6ob00471g

Reference yield: 50.0%

3,5-Bis(trifluoromethyl)benzaldehyde (401-95-6) + 4-(aminomethyl)benzamide (369-53-9) + 1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide (1054543-47-3)

Guidance literature:

With ammonium acetate; acetic acid; at 100 ℃; for 12h;

DOI:10.1002/anie.200802801

Reference yield:

4-bromomethylbenzoic Acid (6232-88-8) → 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide (1054543-47-3)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / ethyl acetate / 15 h / 75 °C / Inert atmosphere

2: ammonium hydroxide / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3: acetic acid; ammonium acetate / 150 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; ammonium acetate; ammonium hydroxide; acetic acid; In dichloromethane; ethyl acetate;

DOI:10.1039/c6ob00471g

upstream raw materials:

3,5-Bis(trifluoromethyl)benzaldehyde

4-(aminomethyl)benzamide

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

4-(bromomethyl)benzamide

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