4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

Base Information

Chemical Name:4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester
CAS No.:1401303-92-1
Molecular Formula:C₃₆H₃₉N₅O₅
Molecular Weight:621.736
Hs Code.:

Synonyms:4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

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Chemical Property of 4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

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Technology Process of 4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

There total 4 articles about 4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1401303-91-0
4-benzyloxy-2-bromo-2-methylbutyric acid benzyl ester

: 1401304-30-0
2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-ol

: 1401303-92-1
4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

Guidance literature:: With caesium carbonate; In acetonitrile; for 3h; Reflux;

Reference yield:

: 100-39-0
benzyl bromide

: 1401303-92-1
4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / 1,4-dioxane; water / 0.75 h / 20 - 90 °C

1.2: 0.58 h / 20 °C

1.3: 18 h / 20 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -30 °C / Inert atmosphere

2.2: 3.5 h / -78 - 0 °C

3.1: caesium carbonate / acetonitrile / 3 h / Reflux

With n-butyllithium; caesium carbonate; diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexanes; water; acetonitrile;

Reference yield:

: 1679-47-6
3-methyltetrahydro-2-furanone

: 1401303-92-1
4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / 1,4-dioxane; water / 0.75 h / 20 - 90 °C

1.2: 0.58 h / 20 °C

1.3: 18 h / 20 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 1.08 h / -78 - -30 °C / Inert atmosphere

2.2: 3.5 h / -78 - 0 °C

3.1: caesium carbonate / acetonitrile / 3 h / Reflux

With n-butyllithium; caesium carbonate; diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexanes; water; acetonitrile;