9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Base Information

Chemical Name:9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
CAS No.:1207455-76-2
Molecular Formula:C₂₆H₂₃FN₄O
Molecular Weight:426.493
Hs Code.:

Synonyms:9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Chemical Property of 9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Technology Process of 9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

There total 11 articles about 9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1207455-80-8
Benzyl 2-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)pyrrolidine-1-carboxylate

: 1207455-76-2
9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: With hydrogen; 1% Pd/C; In methanol; at 20 ℃; for 2h;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207455-76-2
9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: magnesium sulfate / acetonitrile / 96 h / 120 °C

4.1: ethanol / 20 °C

5.1: hydrazine hydrate / methanol / 4 h / 20 °C

6.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With sodium tetrahydroborate; hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 383127-22-8
2-(4-bromo-phenyl)-pyrrolidine

: 1207455-76-2
9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / 1,4-dioxane; water / 20 °C

2: sodium formate; hydroxycarbene / dichlorobis(triphenylphosphine)palladium(II) / 8 h / 100 °C

3: magnesium sulfate / acetonitrile / 96 h / 120 °C

4: ethanol / 20 °C

5: hydrazine hydrate / methanol / 4 h / 20 °C

6: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With hydroxycarbene; hydrogen; sodium formate; magnesium sulfate; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; dichlorobis(triphenylphosphine)palladium(II); In 1,4-dioxane; methanol; ethanol; water; acetonitrile;