5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

Base Information

Chemical Name:5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)
CAS No.:214151-41-4
Molecular Formula:C₂₉H₄₄N₆O₈S₂
Molecular Weight:668.836
Hs Code.:

5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

Synonyms:5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

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Chemical Property of 5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

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Technology Process of 5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

There total 4 articles about 5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 214151-40-3
5H-thiazolo[3,2-a]pyridine-3-carboxamide, 6-amino-N-{4-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-, (3R-(3α,6α,8aα))-(9Cl)

: 1939-99-7
benzenesulfonyl chloride

: 214151-41-4
5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm981013e

Reference yield:

: 149563-21-3
Fmoc-β-turn-dipeptide

: 214151-41-4
5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / EDCl, HOBT / CH₂Cl₂ / Ambient temperature

2: 98 percent / piperidine / CH₂Cl₂ / 0.5 h

3: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/jm981013e

Reference yield:

: carbamic acid, [(3-aminopropyl)carbonimidoyl]bis-, bis(1,1-dimethylethyl) ester monohydrochloride

: 214151-41-4
5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl)

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / EDCl, HOBT / CH₂Cl₂ / Ambient temperature

2: 98 percent / piperidine / CH₂Cl₂ / 0.5 h

3: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/jm981013e