16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

Base Information

Chemical Name:16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester
CAS No.:1254581-04-8
Molecular Formula:C₃₈H₆₅N₃O₈
Molecular Weight:691.949
Hs Code.:

Synonyms:16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

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Chemical Property of 16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

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Technology Process of 16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

There total 5 articles about 16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 57133-29-6
(S)-2,5-bis((tert-butoxycarbonyl)amino)pentanoic acid

: C₂₃H₃₉NO₃

: 1254581-04-8
16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/bc100334t

Reference yield:

: 2536-35-8
16-bromohexadecanoic acid

: 1254581-04-8
16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: water; trifluoroacetic acid / 1 h / 20 °C

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With thionyl chloride; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/bc100334t

Reference yield:

: 123-30-8
4-amino-phenol

: 1254581-04-8
16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 18 h

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: water; trifluoroacetic acid / 1 h / 20 °C

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/bc100334t