(1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester
• CAS No.: 1254581-05-9
• Molecular Formula: C₃₉H₆₉N₅O₇
• Molecular Weight: 720.006
• Mol file: 1254581-05-9.mol

Synonyms:(1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester

Chemical Property of (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester

There total 8 articles about (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester (1254581-04-8) + ethylenediamine (107-15-3,85404-18-8) → (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester (1254581-05-9)

Guidance literature:

at 70 ℃; for 72h;

DOI:10.1021/bc100334t

Reference yield:

C23H39NO3 → (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester (1254581-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

2: 72 h / 70 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/bc100334t

Reference yield:

16-(4-tert-butoxycarbonylaminophenoxy)hexadecanoic acid methyl ester (1254581-03-7) → (1-{4-[15-(2-aminoethylcarbamoyl)pentadecyloxy]phenylcarbamoyl}-4-tert-butoxycabonylaminobutyl)carbamic acid tert-butyl ester (1254581-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: water; trifluoroacetic acid / 1 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: 72 h / 70 °C

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/bc100334t

upstream raw materials:

16-[4-(2,5-bis-[(tert-butoxycaronyl)amino]pentanoylamino)phenoxy]hexadecanoic acid methyl ester

ethylenediamine

16-(4-tert-butoxycarbonylaminophenoxy)hexadecanoic acid methyl ester

16-bromohexadecanoic acid

Downstream raw materials:

[4-tert-butoxylamino-4-(4-{15-[2-(2,3,4,5,6-pentahydroxyhexanoylamino)ethylcabamoyl]pentadecyloxy}phenylcarbamoyl)butyl]carbamic acid tert-butyl ester

16-[4-(2,5-diaminopentanoylamino)phenoxy]hexadecanoicacid[2-(2,3,4,5,6-pentahydroxyhexanoylamino)ethyl]amide