N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide

Base Information

• Chemical Name: N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide
• CAS No.: 1245729-33-2
• Molecular Formula: C₁₈H₃₁NO₃Si
• Molecular Weight: 337.535
• Mol file: 1245729-33-2.mol

Synonyms:N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide

Chemical Property of N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide

There total 1 articles about N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-diethyl 3-hydroxy-5-methoxybenzamide (908609-54-1) + tert-butyldimethylsilyl chloride (18162-48-6) → N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide (1245729-33-2)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201000401

Reference yield: 63.0%

N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide (1245729-33-2) → 3-(tert-butyldimethylsilyloxy)-5-methoxybenzaldehyde (441351-34-4)

Guidance literature:

With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201000401

Reference yield:

N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide (1245729-33-2) → C18H30INO3Si (1228657-95-1)

Guidance literature:

N,N-diethyl 3-(tert-butyldimethylsilyloxy)-5-methoxybenzamide; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; Inert atmosphere;

With iodine; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol403183a

upstream raw materials:

N,N-diethyl 3-hydroxy-5-methoxybenzamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

3-(tert-butyldimethylsilyloxy)-5-methoxybenzaldehyde

C₁₈H₃₀INO₃Si